Access to High Levels of Molecular Complexity by One-Pot Iridium/Enamine Asymmetric Catalysis
Independent workers with team spirit: A catalytic sequence that exploits the compatibility of (chiral) cationic iridium catalysts for the isomerization of primary allylic alcohols to aldehydes with organocatalysts has been developed for the highly enantioselective alpha functionalization of aldehydes (up to 66 % yield, d.r. 49:1, 99 % ee). The reaction displayed useful generality with respect to both the nucleophile and the electrophile.
Références
- Titre
- Access to High Levels of Molecular Complexity by One-Pot Iridium/Enamine Asymmetric Catalysis
- Type de publication
- Article de revue
- Année de publication
- 2011
- Auteurs
- Quintard, Adrien, Alexakis Alexandre, and Mazet Clément
- Revue
- Angewandte Chemie International Edition
- Volume
- 50
- Ticket
- 10
- Pagination
- 2354–2358
Soumis le 7 septembre 2022