Access to bifunctionalized biomolecular platforms using oxime ligation.
This paper describes an efficient oxime ligation strategy to prep. multivalent conjugates wherein peptides alone or in combination with carbohydrate or oxime groups were coupled to a cyclopeptide scaffold. To demonstrate the versatility of this approach, two classes of conjugates have been prepd. In one class, the authors attached two or four peptide sequences to the cyclopeptide core together with free oxime groups, while the second class contains an addnl. substitution with four or two monosaccharides. The well-defined structure of these conjugates was confirmed by high-resoln. mass spectrometry. [on SciFinder(R)]
Références
- Titre
- Access to bifunctionalized biomolecular platforms using oxime ligation.
- Type de publication
- Article de revue
- Année de publication
- 2014
- Auteurs
- Krenek, Karel, Gazak Radek, Daskhan Gour Chand, Garcia Julian, Fiore Michele, Dumy Pascal, Sulc Miroslav, Kren Vladimir, and Renaudet Olivier
- Revue
- Carbohydr. Res.
- Volume
- 393
- Pagination
- 9–14
- ISSN
- 0008-6215
Soumis le 12 avril 2018