Access to bifunctionalized biomolecular platforms using oxime ligation.

This paper describes an efficient oxime ligation strategy to prep. multivalent conjugates wherein peptides alone or in combination with carbohydrate or oxime groups were coupled to a cyclopeptide scaffold. To demonstrate the versatility of this approach, two classes of conjugates have been prepd. In one class, the authors attached two or four peptide sequences to the cyclopeptide core together with free oxime groups, while the second class contains an addnl. substitution with four or two monosaccharides. The well-defined structure of these conjugates was confirmed by high-resoln. mass spectrometry. [on SciFinder(R)]

Références

Titre
Access to bifunctionalized biomolecular platforms using oxime ligation.
Type de publication
Article de revue
Année de publication
2014
Revue
Carbohydr. Res.
Volume
393
Pagination
9–14
ISSN
0008-6215
Soumis le 12 avril 2018