Département de chimie moléculaire

This paper describes an efficient oxime ligation strategy to prep. multivalent conjugates wherein peptides alone or in combination with carbohydrate or oxime groups were coupled to a cyclopeptide scaffold. To demonstrate the versatility of this approach, two classes of conjugates have been prepd. In one class, the authors attached two or four peptide sequences to the cyclopeptide core together with free oxime groups, while the second class contains an addnl. substitution with four or two monosaccharides. The well-defined structure of these conjugates was confirmed by high-resoln. mass spectrometry. [on SciFinder(R)]