Département de chimie moléculaire

New series of enantiopure 3,3'-diiodobinaphthol I (R = Ac, 2-phenylpropanol, 4-tolylformamide, N-isopropylformamide, etc.) and 3,3'-diiodobiphenol-based mols. e.g., II have been synthesized and used as chiral hypervalent iodine oxidn. organocatalysts in the alpha-oxytosylation of propiophenone. These new organocatalysts were compared to previous series of 3,3'-diiodo-1,1'-binaphthalene-2,2'-diol-fused maleimides, two important observations have made: the maleimide moiety is the best moiety for obtaining moderate enantioselectivities, and the presence of an aliph. substituent on the biaryl part of the catalyst enhances the enantioselectivity.