Département de chimie moléculaire

Cyclodecapeptides to mimic the radical site of tyrosyl-containing proteins., Hossain, Mohammed Akhter, Thomas Fabrice, Hamman Sylvain, Saint-Aman Eric, Boturyn Didier, Dumy Pascal, and Pierre Jean-Louis. , J. Pept. Sci., Volume 12, Number 9, p.612–619, (2006)

Redox-Active Biomolecular Architectures and Self-Assembled Monolayers Based on a Cyclodecapeptide Regioselectively Addressable Functional Template., Devillers, Charles H., Boturyn Didier, Bucher Christophe, Dumy Pascal, Labbe Pierre, Moutet Jean-Claude, Royal Guy, and Saint-Aman Eric , Langmuir, Volume 22, Number 19, p.8134–8143, (2006)

Activatable probes for non-invasive small animal fluorescence imaging., Texier, Isabelle, Razkin Jesus, Josserand Veronique, Boturyn Didier, Dumy Pascal, Coll Jean-Luc, and Rizo Philippe. , Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip., Volume 571, Number 1+2, p.165–168, (2007)

In vivo noninvasive optical imaging of receptor-mediated RGD internalization using self-quenched Cy5-labeled RAFT-c(-RGDfK-)4., Jin, Zhao-hui, Razkin Jesus, Josserand Veronique, Boturyn Didier, Grichine Alexei, Texier Isabelle, Favrot Marie-Christine, Dumy Pascal, and Coll Jean-Luc. , Mol. Imaging, Volume 6, Number 1, p.43–55, (2007)

1-Ethoxyethylidene, a New Group for the Stepwise SPPS of Aminooxyacetic Acid Containing Peptides., Foillard, Stephanie, Rasmussen Martin Ohsten, Razkin Jesus, Boturyn Didier, and Dumy Pascal , J. Org. Chem., Volume 73, Number 3, p.983–991, (2008)

Chemical and Biological Evaluations of an 111In-Labeled RGD-Peptide Targeting Integrin Alpha(V) Beta(3) in a Preclinical Tumor Model., Ahmadi, Mitra, Sancey Lucie, Briat Arnaud, Riou Laurent, Boturyn Didier, Dumy Pascal, Fagret Daniel, Ghezzi Catherine, and Vuillez Jean-Philippe. , Cancer Biother. Radiopharm., Volume 23, Number 6, p.691–700, (2008)

RAFT Nano-constructs: surfing to biological applications., Boturyn, Didier, Defrancq Eric, Dolphin Gunnar T., Garcia Julian, Labbe Pierre, Renaudet Olivier, and Dumy Pascal , J. Pept. Sci., Volume 14, Number 2, p.224–240, (2008)

Synthesis and biological characterization of targeted pro-apoptotic peptide., Foillard, Stephanie, Jin Zhao-hui, Garanger Elisabeth, Boturyn Didier, Favrot Marie-Christine, Coll Jean-Luc, and Dumy Pascal , ChemBioChem, Volume 9, Number 14, p.2326–2332, (2008)

Biomolecular assembly by iterative oxime ligations., Renaudet, Olivier, Boturyn Didier, and Dumy Pascal , Bioorg. Med. Chem. Lett., Volume 19, Number 14, p.3880–3883, (2009)

Clustering and Internalization of Integrin $\alpha$v$\beta$3 With a Tetrameric RGD-synthetic Peptide., Sancey, Lucie, Garanger Elisabeth, Foillard Stephanie, Schoehn Guy, Hurbin Amandine, Albiges-Rizo Corinne, Boturyn Didier, Souchier Catherine, Grichine Alexei, Dumy Pascal, et al. , Mol. Ther., Volume 17, Number 5, p.837–843, (2009)

Drug development in oncology assisted by noninvasive optical imaging., Sancey, L, Dufort S, Josserand V, Keramidas M, Righini C, Rome C, Faure A.-C., Foillard S, Roux S, Boturyn Didier, et al. , Int. J. Pharm., Volume 379, Number 2, p.309–316, (2009)

A Gadolinium-Binding Cyclodecapeptide with a Large High-Field Relaxivity Involving Second-Sphere Water., Bonnet, Celia S., Fries Pascal H., Crouzy Serge, Seneque Olivier, Cisnetti Federico, Boturyn Didier, Dumy Pascal, and Delangle Pascale. , Chem. - A Eur. J., Volume 15, Number 29, p.7083–7093, S7083/1–S7083/8, (2009)

Highly efficient cell adhesion on beads functionalized with clustered peptide ligands., Foillard, Stephanie, Dumy Pascal, and Boturyn Didier , Org. Biomol. Chem., Volume 7, Number 20, p.4159–4162, (2009)

One-pot approach to well-defined biomolecular assemblies by orthogonal chemoselective ligations., Galibert, Mathieu, Dumy Pascal, and Boturyn Didier , Angew. Chemie, Int. Ed., Volume 48, Number 14, p.2576–2579, (2009)

Targeted delivery of activatable fluorescent pro-apoptotic peptide into live cells., Foillard, Stephanie, Sancey Lucie, Coll Jean-Luc, Boturyn Didier, and Dumy Pascal , Org. Biomol. Chem., Volume 7, Number 2, p.221–224, (2009)

Application of click-click chemistry to the synthesis of new multivalent RGD conjugates., Galibert, Mathieu, Sancey Lucie, Renaudet Olivier, Coll Jean-Luc, Dumy Pascal, and Boturyn Didier , Org. Biomol. Chem., Volume 8, Number 22, p.5133–5138, (2010)

Cell adhesion through clustered ligand on fluid supported lipid bilayers., Sandrin, Ludivine, Guerente Liliane, Bernstein Amandine, Basit Hajra, Labbe Pierre, Dumy Pascal, and Boturyn Didier , Org. Biomol. Chem., Volume 8, Number 7, p.1531–1534, (2010)

Molecular engineering of biomolecules for nanobio-sciences., Renaudet, Olivier, Garcia Julian, Boturyn Didier, Spinelli Nicolas, Defrancq Eric, Labbe Pierre, and Dumy Pascal , Int. J. Nanotechnol., Volume 7, Number 4/5/6/7/8, p.738–752, (2010)

Non-invasive tools for detecting vulnerable atherosclerotic plaques., Fagret, Daniel, Ghezzi Catherine, Dumy Pascal, Riou Laurent, and Boturyn Didier , (2010)

RGD-cyclam conjugate: Synthesis and potential application for positron emission tomography., Galibert, Mathieu, Jin Zhao-hui, Furukawa Takako, Fukumura Toshimitsu, Saga Tsuneo, Fujibayashi Yasuhisa, Dumy Pascal, and Boturyn Didier , Bioorg. Med. Chem. Lett., Volume 20, Number 18, p.5422–5425, (2010)

Access to Biomolecular Assemblies through One-Pot Triple Orthogonal Chemoselective Ligations., Galibert, Mathieu, Renaudet Olivier, Dumy Pascal, and Boturyn Didier , Angew. Chemie, Int. Ed., Volume 50, Number 8, p.1901–1904, S1901/1–S1901/32, (2011)

Noninvasive visualization and quantification of tumor $\alpha$V$\beta$3 integrin expression using a novel positron emission tomography probe, 64Cu-cyclam-RAFT-c(-RGDfK-)4., Jin, Zhao-hui, Furukawa Takako, Galibert Mathieu, Boturyn Didier, Coll Jean-Luc, Fukumura Toshimitsu, Saga Tsuneo, Dumy Pascal, and Fujibayashi Yasuhisa. , Nucl. Med. Biol., Volume 38, Number 4, p.529–540, (2011)

Redox strategy for reversible attachment of biomolecules using bifunctional linkers., Dubacheva, Galina V., Galibert Mathieu, Guerente Liliane, Dumy Pascal, Boturyn Didier, and Labbe Pierre , Chem. Commun. (Cambridge, United Kingdom), Volume 47, Number 12, p.3565–3567, (2011)

Targeted delivery of a proapoptotic peptide to tumors in vivo., Dufort, Sandrine, Sancey Lucie, Hurbin Amandine, Foillard Steephanie, Boturyn Didier, Dumy Pascal, and Coll Jean-Luc. , J. Drug Target., Volume 19, Number 7, p.582–588, (2011)

Fluorescent molecules for surgery., Dumy, Pascal, Wenk Christiane, Claron Michael, Coll Jean-Luc, Allard Odile, and Boturyn Didier , Actual. Chim., Volume 366, p.23–28, (2012)

Positron emission tomography imaging of tumor angiogenesis and monitoring of antiangiogenic efficacy using the novel tetrameric peptide probe 64Cu-cyclam-RAFT-c(-RGDfK-)4., Jin, Zhao-hui, Furukawa Takako, Claron Michael, Boturyn Didier, Coll Jean-Luc, Fukumura Toshimitsu, Fujibayashi Yasuhisa, Dumy Pascal, and Saga Tsuneo. , Angiogenesis, Volume 15, Number 4, p.569–580, (2012)

Reduction of renal uptake of 111In-DOTA-labeled and A700-labeled RAFT-RGD during integrin $\alpha$v$\beta$3 targeting using single photon emission computed tomography and optical imaging., Briat, Arnaud, Wenk Christiane H. F., Ahmadi Mitra, Claron Michael, Boturyn Didier, Josserand Veronique, Dumy Pascal, Fagret Daniel, Coll Jean-Luc, Ghezzi Catherine, et al. , Cancer Sci., Volume 103, Number 6, p.1105–1110, (2012)

Engineering of biomolecules for sensing and imaging applications., Ulrich, S, Dumy Pascal, Boturyn Didier, and Renaudet Olivier , J. Drug Deliv. Sci. Technol., Volume 23, Number 1, p.5–15, (2013)

In vivo molecular imaging of atherosclerotic lesions in ApoE-/- mice using VCAM-1-specific, 99Tc-labeled peptidic sequences., Dimastromatteo, Julien, Broisat Alexis, Perret Pascale, Ahmadi Mitra, Boturyn Didier, Dumy Pascal, Fagret Daniel, Riou Laurent M., and Ghezzi Catherine. , J. Nucl. Med., Volume 54, Number 8, p.1442–1449, (2013)

Integrin and matrix metalloprotease dual-targeting with an MMP substrate-RGD conjugate., Wenk, Christiane H. F., Josserand Veronique, Dumy Pascal, Coll Jean-Luc, and Boturyn Didier , Org. Biomol. Chem., Volume 11, Number 3, p.448–452, (2013)

Micro-positron emission tomography/contrast-enhanced computed tomography imaging of orthotopic pancreatic tumor-bearing mice using the $\alpha$v$\beta$3 integrin tracer 64Cu-labeled cyclam-RAFT-c(-RGDfK-)4., Aung, Winn, Jin Zhao-hui, Furukawa Takako, Claron Michael, Boturyn Didier, Sogawa Chizuru, Tsuji Atsushi B., Wakizaka Hidekatsu, Fukumura Toshimitsu, Fujibayashi Yasuhisa, et al. , Mol. Imaging, Volume 12, Number 6, p.376–387, (2013)

Near-infrared optical guided surgery of highly infiltrative fibrosarcomas in cats using an anti-$\alpha$vss3 integrin molecular probe., Wenk, Christiane H. F., Ponce Frederique, Guillermet Stephanie, Tenaud Corinne, Boturyn Didier, Dumy Pascal, Watrelot-Virieux Dorothee, Carozzo Claude, Josserand Veronique, and Coll Jean-Luc. , Cancer Lett. (New York, NY, United States), Volume 334, Number 2, p.188–195, (2013)

Co-liposomes comprising a lipidated multivalent RGD-peptide and a cationic gemini cholesterol induce selective gene transfection in $\alpha$v$\beta$3 and $\alpha$v$\beta$5 integrin receptor-rich cancer cells., Misra, Santosh K., Kondaiah Paturu, Bhattacharya Santanu, Boturyn Didier, and Dumy Pascal , J. Mater. Chem. B Mater. Biol. Med., Volume 2, Number 35, p.5758–5767, (2014)

Oxime Ligation: A Chemoselective Click-Type Reaction for Accessing Multifunctional Biomolecular Constructs., Ulrich, Sebastien, Boturyn Didier, Marra Alberto, Renaudet Olivier, and Dumy Pascal , Chem. - A Eur. J., Volume 20, Number 1, p.34–41, (2014)

PET imaging and biodistribution analysis of the effects of succinylated gelatin combined with L-lysine on renal uptake and retention of 64Cu-cyclam-RAFT-c(-RGDfK-)4in vivo., Jin, Zhao-hui, Furukawa Takako, Sogawa Chizuru, Claron Michael, Aung Winn, Tsuji Atsushi B., Wakizaka Hidekatsu, Zhang Ming-Rong, Boturyn Didier, Dumy Pascal, et al. , Eur. J. Pharm. Biopharm., Volume 86, Number 3, p.478–486, (2014)

Redox-driven host-guest interactions allow the controlled release of captured cells on RGD-functionalized surfaces., Thakar, Dhruv, Guerente Liliane, Claron Michael, Wenk Christiane H. F., Dejeu Jérôme, Dumy Pascal, Labbe Pierre, and Boturyn Didier , ChemBioChem, Volume 15, Number 3, p.377–381, (2014)

Biomolecular Assemblies Combining Two Orthogonal Copper-Mediated Ligations in a One-Pot Reaction., Grassin, Adrien, Claron Michael, and Boturyn Didier , Chem. - A Eur. J., Volume 21, Number 16, p.6022–6026, (2015)

Controlled surface density of RGD ligands for cell adhesion: evidence for ligand specificity by using QCM-D., Sandrin, L, Thakar D, Goyer C, Labbe Pierre, Boturyn Didier, and Guerente Liliane , J. Mater. Chem. B Mater. Biol. Med., Volume 3, Number 27, p.5577–5587, (2015)

Multivalency: influence of the residence time and the retraction rate on rupture forces measured by AFM., Bacharouche, Jalal, Degardin Melissa, Jierry Loic, Carteret Cedric, Lavalle Philippe, Hemmerle Joseph, Senger Bernard, Auzely Rachel, Boulmedais Fouzia, Boturyn Didier, et al. , J. Mater. Chem. B Mater. Biol. Med., Volume 3, Number 9, p.1801–1812, (2015)

Targeted radionuclide therapy with RAFT-RGD radiolabelled with 90Y or 177Lu in a mouse model of $\alpha$v$\beta$3-expressing tumours., Bozon-Petitprin, A, Bacot S, Gauchez A S., Ahmadi M, Bourre J C., Marti-Batlle D, Perret P, Broisat A, Riou L M., Claron M, et al. , Eur. J. Nucl. Med. Mol. Imaging, Volume 42, Number 2, p.252–263, (2015)

$\alpha$V$\beta$3 Integrin-Targeted Radionuclide Therapy with 64Cu-cyclam-RAFT-c(-RGDfK-)4., Jin, Zhao-hui, Furukawa Takako, Degardin Melissa, Sugyo Aya, Tsuji Atsushi B., Yamasaki Tomoteru, Kawamura Kazunori, Fujibayashi Yasuhisa, Zhang Ming-Rong, Boturyn Didier, et al. , Mol. Cancer Ther., Volume 15, Number 9, p.2076–2085, (2016)

From Peptide Aptamers to Inhibitors of FUR, Bacterial Transcriptional Regulator of Iron Homeostasis and Virulence., Mathieu, Sophie, Cisse Cheickna, Vitale Sylvia, Ahmadova Aynur, Degardin Melissa, Perard Julien, Colas Pierre, Miras Roger, Boturyn Didier, Covès Jacques, et al. , ACS Chem. Biol., Volume 11, Number 9, p.2519–2528, (2016)

Influence of Pre-organised Architecture on Cell Adhesion by Using Multivalent RGD Compounds., Grassin, Adrien, Jourdan Muriel, Dumy Pascal, and Boturyn Didier , ChemBioChem, Volume 17, Number 6, p.515–520, (2016)

Preparation of dihydropyrene derivatives and their uses., Royal, Guy, Cobo Saioa, Saint-Aman Eric, Josserand Veronique, and Boturyn Didier , (2016)

67Cu-Radiolabeling of a multimeric RGD peptide for αVβ3 integrin-targeted radionuclide therapy: stability, therapeutic efficacy, and safety studies in mice., Jin, Zhao-hui, Furukawa Takako, Ohya Tomoyuki, Degardin Melissa, Sugyo Aya, Tsuji Atsushi B., Fujibayashi Yasuhisa, Zhang Ming-Rong, Higashi Tatsuya, Boturyn Didier, et al. , Nucl. Med. Commun., Volume 38, Number 4, p.347–355, (2017)

Binding of the chemokine CXCL12α to its natural extracellular matrix ligand heparan sulfate enables myoblast adhesion and facilitates cell motility., Thakar, Dhruv, Dalonneau Fabien, Migliorini Elisa, Lortat-Jacob Hugues, Boturyn Didier, Albiges-Rizo Corinne, Guerente Liliane, Picart Catherine, and Richter Ralf P. , Biomaterials, Volume 123, p.24–38, (2017)

Development of a selective cell capture and release assay: impact of clustered RGD ligands., Degardin, Melissa, Thakar D, Claron M, Richter Ralf P., Guerente Liliane, and Boturyn Didier , J. Mater. Chem. B Mater. Biol. Med., Volume 5, Number 24, p.4745–4753, (2017)

Luminescent Zinc Fingers: Zn-Responsive Neodymium Near-Infrared Emission in Water., Isaac, Manon, Raibaut Laurent, Cepeda Celine, Roux Amandine, Boturyn Didier, Eliseeva Svetlana V., Petoud Stephane, and Seneque Olivier , Chem. - A Eur. J., Volume 23, Number 46, p.10992–10996, (2017)

"Polymultivalent" Polymer-Peptide Cluster Conjugates for an Enhanced Targeting of Cells Expressing $\alpha$v$\beta$3 Integrins., Duret, Damien, Grassin Adrien, Henry Maxime, Jacquet Thibault, Thoreau Fabien, Denis-Quanquin Sandrine, Coll Jean-Luc, Boturyn Didier, Favier Arnaud, and Charreyre Marie-Therese. , Bioconjug. Chem., Volume 28, Number 9, p.2241–2245, (2017)

Systemic Delivery of Tumor-Targeted Bax-Derived Membrane-Active Peptides for the Treatment of Melanoma Tumors in a Humanized SCID Mouse Model., Karageorgis, Anastassia, Claron Michael, Juge Romain, Aspord Caroline, Thoreau Fabien, Leloup Claire, Kucharczak Jerome, Plumas Joel, Henry Maxime, Hurbin Amandine, et al. , Mol. Ther., Volume 25, Number 2, p.534–546, (2017)