Département de chimie moléculaire

Access to a stabilized i-motif DNA structure through four successive ligation reactions on a cyclopeptide scaffold, Devaux, Alexandre, Bonnat Laureen, Lavergne Thomas, and Defrancq Eric , Org. Biomol. Chem., 07/2020, Volume 18, p.6394-6406, (2020)

Assessment of new 2'-O-acetalester protecting groups for regular RNA synthesis and original 2'-modified proRNA, Martin, A. R., Lavergne Thomas, Vasseur J. J., and Debart F. , Bioorganic & Medicinal Chemistry Letters, Volume 19, Number 15, p.4046-9, (2009)

A base-labile group for 2'-OH protection of ribonucleosides: a major challenge for RNA synthesis, Lavergne, Thomas, Bertrand J. R., Vasseur J. J., and Debart F. , Chemistry, Volume 14, Number 30, p.9135-8, (2008)

Binding of metalloporphyrins to G-quadruplex DNA: The role of the central metal., Dejeu, Jérôme, Lavergne Thomas, Nora Jeremie Della, Defrancq Eric, and Pratviel Genevieve. , Inorganica Chim. Acta, Volume 452, p.98–103, (2016)

The biolabile 2'-O-pivaloyloxymethyl modification in an RNA helix: an NMR solution structure, Baraguey, C., Lescrinier E., Lavergne Thomas, Debart F., Herdewijn P., and Vasseur J. J. , Organic & Biomolecular Chemistry, Volume 11, Number 16, p.2638-47, (2013)

Chemical synthesis of RNA with base-labile 2'-o-(pivaloyloxymethyl)-protected ribonucleoside phosphoramidites, Lavergne, Thomas, Janin M., Dupouy C., Vasseur J. J., and Debart F. , Curr Protoc Nucleic Acid Chem, Volume Chapter 3, p.Unit3 19, (2010)

Construction of anti-parallel G-quadruplexes through sequential templated click., Bonnet, Romaric, Lavergne Thomas, Gennaro Béatrice, Spinelli Nicolas, and Defrancq Eric , Chem. Commun. (Cambridge, United Kingdom), Volume 51, Number 23, p.4850–4853, (2015)

Efficient and sequence-independent replication of DNA containing a third base pair establishes a functional six-letter genetic alphabet, Malyshev, D. A., Dhami K., Quach H. T., Lavergne Thomas, Ordoukhanian P., Torkamani A., and Romesberg F. E. , Proc Natl Acad Sci U S A, Volume 109, Number 30, p.12005-10, (2012)

Efficient Inhibition of Telomerase by Nickel-Salophen Complexes., Lecarme, Laureline, Prado Enora, De Rache Aurore, Nicolau-Travers Marie-Laure, Gellon Gisèle, Dejeu Jérôme, Lavergne Thomas, Jamet Hélène, Gomez Dennis, Mergny Jean-Louis, et al. , ChemMedChem, Volume 11, Number 11, p.1133–1136, (2016)

Efficient solid-phase chemical synthesis of 5'-triphosphates of DNA, RNA, and their analogues, Zlatev, I., Lavergne Thomas, Debart F., Vasseur J. J., Manoharan M., and Morvan F. , Organic Letters, Volume 12, Number 10, p.2190-3, (2010)

Expanding the scope of replicable unnatural DNA: stepwise optimization of a predominantly hydrophobic base pair, Lavergne, Thomas, Degardin Melissa, Malyshev D. A., Quach H. T., Dhami K., Ordoukhanian P., and Romesberg F. E. , Journal of the American Chemical Society, Volume 135, Number 14, p.5408-19, (2013)

FRET Characterization of Complex Conformational Changes in a Large 16S Ribosomal RNA Fragment Site-Specifically Labeled Using Unnatural Base Pairs, Lavergne, Thomas, Lamichhane R., Malyshev D. A., Li Z., Li L., Sperling E., Williamson J. R., Millar D. P., and Romesberg F. E. , Acs Chemical Biology, Volume 11, Number 5, p.1347-53, (2016)

Influence of the SPR Experimental Conditions on the G-Quadruplex DNA Recognition by Porphyrin Derivatives., Prado, E, Bonnat L, Bonnet Hugues, Lavergne Thomas, Van der Heyden Angeline, Pratviel G, Dejeu Jérôme, and Defrancq Eric , Langmuir, Volume 34, Number 43, p.13057–13064, (2018)

KlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometry, Betz, K., Malyshev D. A., Lavergne Thomas, Welte W., Diederichs K., Dwyer T. J., Ordoukhanian P., Romesberg F. E., and Marx A. , Nature Chemical Biology, Volume 8, Number 7, p.612-4, (2012)

Major groove substituents and polymerase recognition of a class of predominantly hydrophobic unnatural base pairs, Lavergne, Thomas, Malyshev D. A., and Romesberg F. E. , Chemistry, Volume 18, Number 4, p.1231-9, (2012)

Natural-like replication of an unnatural base pair for the expansion of the genetic alphabet and biotechnology applications, Li, L., Degardin Melissa, Lavergne Thomas, Malyshev D. A., Dhami K., Ordoukhanian P., and Romesberg F. E. , Journal of the American Chemical Society, Volume 136, Number 3, p.826-9, (2014)

New Ruthenium-Based Probes for Selective G-Quadruplex Targeting., Piraux, Guillaume, Bar Laure, Abraham Michael, Lavergne Thomas, Jamet Hélène, Dejeu Jérôme, Marcelis Lionel, Defrancq Eric, and Elias Benjamin. , Chem. - A Eur. J., Volume 23, Number 49, p.11872–11880, (2017)

Scaffold stabilization of a G-triplex and study of its interactions with G-quadruplex targeting ligands., Bonnat, Laureen, Dautriche Maelle, Saidi Taous, Revol-Cavalier Johana, Dejeu Jérôme, Defrancq Eric, and Lavergne Thomas , Org. Biomol. Chem., Volume 17, p.8726–8736, (2019)

Scaffold stabilization of a G-triplex and study of its interactions with G-quadruplex targeting ligands, Bonnat, Laureen, Dautriche Maelle, Saidi Taous, Revol-Cavalier Johana, Dejeu Jérôme, Defrancq Eric, and Lavergne Thomas , Org. Biomol. Chem., Volume 17, p.8726-8736, (2019)

A semisynthetic organism engineered for the stable expansion of the genetic alphabet., Zhang, Yorke, Lamb Brian M., Feldman Aaron W., Zhou Anne Xiaozhou, Lavergne Thomas, Li Lingjun, and Romesberg Floyd E. , Proc. Natl. Acad. Sci. U. S. A., Volume 114, Number 6, p.1317–1322, (2017)

A semi-synthetic organism with an expanded genetic alphabet, Malyshev, D. A., Dhami K., Lavergne Thomas, Chen T., Dai N., Foster J. M., Correa, Jr. I. R., and Romesberg F. E. , Nature, Volume 509, Number 7500, p.385-8, (2014)

Site-specific labeling of DNA and RNA using an efficiently replicated and transcribed class of unnatural base pairs, Seo, Y. J., Malyshev D. A., Lavergne Thomas, Ordoukhanian P., and Romesberg F. E. , Journal of the American Chemical Society, Volume 133, Number 49, p.19878-88, (2011)

Site-specifically arraying small molecules or proteins on DNA using an expanded genetic alphabet, Li, Z., Lavergne Thomas, Malyshev D. A., Zimmermann J., Adhikary R., Dhami K., Ordoukhanian P., Sun Z., Xiang J., and Romesberg F. E. , Chemistry, Volume 19, Number 42, p.14205-14209, (2013)

Structural insights into DNA replication without hydrogen bonds, Betz, K., Malyshev D. A., Lavergne Thomas, Welte W., Diederichs K., Romesberg F. E., and Marx A. , Journal of the American Chemical Society, Volume 135, Number 49, p.18637-43, (2013)

Surface plasmon resonance study of the interaction of N-methyl mesoporphyrin IX with G-quadruplex DNA, Perenon, M, Bonnet Hugues, Lavergne Thomas, Dejeu Jérôme, and Defrancq Eric , Phys. Chem. Chem. Phys., 02/2020, Volume 22, p.4158-4164, (2020)

Surface-immobilized DNAzyme-type biocatalysis., Stefan, Loic, Lavergne Thomas, Spinelli Nicolas, Defrancq Eric, and Monchaud David. , Nanoscale, Volume 6, Number 5, p.2693–2701, (2014)

Synthesis and preliminary evaluation of pro-RNA 2'-O-masked with biolabile pivaloyloxymethyl groups in an RNA interference assay, Lavergne, Thomas, Baraguey C., Dupouy C., Parey N., Wuensche W., Sczakiel G., Vasseur J. J., and Debart F. , Journal of Organic Chemistry, Volume 76, Number 14, p.5719-31, (2011)

Templated Formation of Discrete RNA and DNA:RNA Hybrid G-Quadruplexes and Their Interactions with Targeting Ligands., Bonnat, Laureen, Dejeu Jérôme, Bonnet Hugues, Gennaro Béatrice, Jarjayes Olivier, Thomas Fabrice, Lavergne Thomas, and Defrancq Eric , Chem. - A Eur. J., Volume 22, Number 9, p.3139–3147, (2016)

Template-mediated stabilization of a DNA G-quadruplex formed in the HIV-1 promoter and comparative binding studies., Bonnat, Laureen, Bar Laure, Gennaro Béatrice, Bonnet Hugues, Jarjayes Olivier, Thomas Fabrice, Dejeu Jérôme, Defrancq Eric, and Lavergne Thomas , Chem. - A Eur. J., Volume 23, Number 23, p.5602–5613, (2017)