Département de chimie moléculaire

Efficient and sequence-independent replication of DNA containing a third base pair establishes a functional six-letter genetic alphabet, Malyshev, D. A., Dhami K., Quach H. T., Lavergne Thomas, Ordoukhanian P., Torkamani A., and Romesberg F. E. , Proc Natl Acad Sci U S A, Volume 109, Number 30, p.12005-10, (2012)

Expanding the scope of replicable unnatural DNA: stepwise optimization of a predominantly hydrophobic base pair, Lavergne, Thomas, Degardin Melissa, Malyshev D. A., Quach H. T., Dhami K., Ordoukhanian P., and Romesberg F. E. , Journal of the American Chemical Society, Volume 135, Number 14, p.5408-19, (2013)

FRET Characterization of Complex Conformational Changes in a Large 16S Ribosomal RNA Fragment Site-Specifically Labeled Using Unnatural Base Pairs, Lavergne, Thomas, Lamichhane R., Malyshev D. A., Li Z., Li L., Sperling E., Williamson J. R., Millar D. P., and Romesberg F. E. , Acs Chemical Biology, Volume 11, Number 5, p.1347-53, (2016)

KlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometry, Betz, K., Malyshev D. A., Lavergne Thomas, Welte W., Diederichs K., Dwyer T. J., Ordoukhanian P., Romesberg F. E., and Marx A. , Nature Chemical Biology, Volume 8, Number 7, p.612-4, (2012)

Major groove substituents and polymerase recognition of a class of predominantly hydrophobic unnatural base pairs, Lavergne, Thomas, Malyshev D. A., and Romesberg F. E. , Chemistry, Volume 18, Number 4, p.1231-9, (2012)

Natural-like replication of an unnatural base pair for the expansion of the genetic alphabet and biotechnology applications, Li, L., Degardin Melissa, Lavergne Thomas, Malyshev D. A., Dhami K., Ordoukhanian P., and Romesberg F. E. , Journal of the American Chemical Society, Volume 136, Number 3, p.826-9, (2014)

A semi-synthetic organism with an expanded genetic alphabet, Malyshev, D. A., Dhami K., Lavergne Thomas, Chen T., Dai N., Foster J. M., Correa, Jr. I. R., and Romesberg F. E. , Nature, Volume 509, Number 7500, p.385-8, (2014)

Site-specific labeling of DNA and RNA using an efficiently replicated and transcribed class of unnatural base pairs, Seo, Y. J., Malyshev D. A., Lavergne Thomas, Ordoukhanian P., and Romesberg F. E. , Journal of the American Chemical Society, Volume 133, Number 49, p.19878-88, (2011)

Site-specifically arraying small molecules or proteins on DNA using an expanded genetic alphabet, Li, Z., Lavergne Thomas, Malyshev D. A., Zimmermann J., Adhikary R., Dhami K., Ordoukhanian P., Sun Z., Xiang J., and Romesberg F. E. , Chemistry, Volume 19, Number 42, p.14205-14209, (2013)

Structural insights into DNA replication without hydrogen bonds, Betz, K., Malyshev D. A., Lavergne Thomas, Welte W., Diederichs K., Romesberg F. E., and Marx A. , Journal of the American Chemical Society, Volume 135, Number 49, p.18637-43, (2013)