Département de chimie moléculaire

New Solid Support for the Synthesis of 3'-Oligonucleotide Conjugates through Glyoxylic Oxime Bond Formation., Spinelli, Nicolas, Edupuganti Om Prakash, Defrancq Eric, and Dumy Pascal , Org. Lett., Volume 9, Number 2, p.219–222, (2007)

New Ruthenium-Based Probes for Selective G-Quadruplex Targeting., Piraux, Guillaume, Bar Laure, Abraham Michael, Lavergne Thomas, Jamet Hélène, Dejeu Jérôme, Marcelis Lionel, Defrancq Eric, and Elias Benjamin. , Chem. - A Eur. J., Volume 23, Number 49, p.11872–11880, (2017)

Negative SPR Signals during Low Molecular Weight Analyte Recognition, Bonnet, Hugues, Coche-Guérente L., Defrancq Eric, Spinelli N., Van der Heyden Angeline, and Dejeu Jérôme , Analytical Chemistry, 02/2021, Volume 93, Issue 8, p.4134–4140, (2021)

Molecular engineering of biomolecules for nanobio-sciences., Renaudet, Olivier, Garcia Julian, Boturyn Didier, Spinelli Nicolas, Defrancq Eric, Labbe Pierre, and Dumy Pascal , Int. J. Nanotechnol., Volume 7, Number 4/5/6/7/8, p.738–752, (2010)

Methods for investigating G-quadruplex DNA/ligand interactions., Murat, Pierre, Singh Yashveer, and Defrancq Eric , Chem. Soc. Rev., Volume 40, Number 11, p.5293–5307, (2011)

Metal-Complex/DNA Conjugates: A Versatile Building Block for DNA Nanoarrays., Ghosh, Sumana, and Defrancq Eric , Chem. - A Eur. J., Volume 16, Number 43, p.12780–12787, (2010)

Macrocyclic Host-Dye Reporter for Sensitive Sandwich-Type Fluorescent Aptamer Sensor., Yang, Cheng, Spinelli Nicolas, Perrier Sandrine, Defrancq Eric, and Peyrin Eric. , Anal. Chem. (Washington, DC, United States), Volume 87, Number 6, p.3139–3143, (2015)

Label-free photoelectrochemical detection of double-stranded HIV DNA by means of a metallointercalator-functionalized electrogenerated polymer., Haddache, Fatima, Le Goff Alan, Reuillard Bertrand, Gorgy Karine, Gondran Chantal, Spinelli Nicolas, Defrancq Eric, and Cosnier Serge , Chem. - A Eur. J., Volume 20, Number 47, p.15555–15560, (2014)

A label-free photoelectrochemical cocaine aptasensor based on an electropolymerized ruthenium-intercalator complex., Haddache, Fatima, Le Goff Alan, Spinelli Nicolas, Gairola Priyanka, Gorgy Karine, Gondran Chantal, Defrancq Eric, and Cosnier Serge , Electrochim. Acta, Volume 219, p.82–87, (2016)

Label-free impedimetric thrombin sensor based on poly(pyrrole-nitrilotriacetic acid)-aptamer film, Xu, Hui, Gorgy Karine, Gondran Chantal, Le Goff Alan, Spinelli Nicolas, Lopez Christian, Defrancq Eric, and Cosnier Serge , Biosensors and Bioelectronics, Volume 41, p.90 - 95, (2013)

Label-free femtomolar detection of target DNA by impedimetric DNA sensor based on poly(pyrrole-nitrilotriacetic acid) film., Baur, Jessica, Gondran Chantal, Holzinger Michael, Defrancq Eric, Perrot Hubert, and Cosnier Serge , Anal. Chem. (Washington, DC, United States), Volume 82, Number 3, p.1066–1072, (2010)

Interaction of Polycationic Ni(II)-Salophen Complexes with G-Quadruplex DNA., Lecarme, Laureline, Prado Enora, De Rache Aurore, Nicolau-Travers Marie-Laure, Bonnet Romaric, Van der Heyden Angeline, Philouze Christian, Gomez Dennis, Mergny Jean-Louis, Jamet Hélène, et al. , Inorg. Chem., Volume 53, Number 23, p.12519–12531, (2014)

Influence of the SPR Experimental Conditions on the G-Quadruplex DNA Recognition by Porphyrin Derivatives., Prado, E, Bonnat L, Bonnet Hugues, Lavergne Thomas, Van der Heyden Angeline, Pratviel G, Dejeu Jérôme, and Defrancq Eric , Langmuir, Volume 34, Number 43, p.13057–13064, (2018)

Influence of Aptamer Surface Coverage on Small Target Recognition: A SPR and QCM-D Comparative Study, MacDonald, Hannah, Bonnet Hugues, Van der Heyden Angeline, Defrancq Eric, Spinelli Nicolas, Guerente Liliane, and Dejeu Jérôme , J. Phys. Chem. C, Volume 123, p.13561–13568, (2019)

Improvement of porphyrins for G-quadruplex DNA targeting., Romera, Carmen, Bombarde Oriane, Bonnet Romaric, Gomez Dennis, Dumy Pascal, Calsou Patrick, Gwan Jean-Fang, Lin Jung-Hsin, Defrancq Eric, and Pratviel Genevieve. , Biochimie, Volume 93, Number 8, p.1310–1317, (2011)

Impact of Conformational Transitions on SPR Signals-Theoretical Treatment and Application in Small Analytes/Aptamer Recognition., Dejeu, Jérôme, Bonnet Hugues, Spinelli Nicolas, Defrancq Eric, Guerente Liliane, Van der Heyden Angeline, and Labbe Pierre. , J. Phys. Chem. C, Volume 122, Number 37, p.21521–21530, (2018)

Highly Sensitive Bisphenol-A Electrochemical Aptasensor Based on Poly(Pyrrole-Nitrilotriacetic Acid)-Aptamer Film., Kazane, Imen, Gorgy Karine, Gondran Chantal, Spinelli Nicolas, Zazoua Ali, Defrancq Eric, and Cosnier Serge , Anal. Chem. (Washington, DC, United States), Volume 88, Number 14, p.7268–7273, (2016)

Highly DNA-Photoreactive Ruthenium 1,4,5,8-Tetraazaphenanthrene Complex Conjugated to the TAT Peptide: Efficient Vectorization inside HeLa Cells without Phototoxicity - The Importance of Cellular Distribution., Marcelis, Lionel, Kajouj Sofia, Ghesquiere Jonathan, Fettweis Gregory, Coupienne Isabelle, Lartia Remy, Surin Mathieu, Defrancq Eric, Piette Jacques, Moucheron Cecile, et al. , Eur. J. Inorg. Chem., Volume 2016, Number 18, p.2902–2911, (2016)

Glycoclusters on oligonucleotide and PNA scaffolds: synthesis and applications., Spinelli, Nicolas, Defrancq Eric, and Morvan Francois. , Chem. Soc. Rev., Volume 42, Number 11, p.4557–4573, (2013)

Flexible RuII Schiff Base Complexes: G-Quadruplex DNA Binding and Photo-Induced Cancer Cell Death, Gillard, Martin, Weynand Justin, Bonnet Hugues, Loiseau Frédérique, Decottignies Anabelle, Dejeu Jérôme, Defrancq Eric, and Elias Benjamin , Chemistry – A European Journal, Volume 26, p.13849-13860, (2020)

Evaluation of a new biocompatible poly(N-(morpholino ethyl methacrylate))-based copolymer for the delivery of ruthenium oligonucleotides, targeting HPV16 E6 oncogene., Reschner, Anca, Shim Yong Ho, Dubois Philippe, Delvenne Philippe, Evrard Brigitte, Marcelis Lionel, Moucheron Cecile, De Mesmaeker Andree Kirsch-, Defrancq Eric, Raes Martine, et al. , J. Biomed. Nanotechnol., Volume 9, Number 8, p.1432–1440, (2013)

Electrogenerated trisbipyridyl Ru(II)-/nitrilotriacetic-polypyrene copolymer for the easy fabrication of label-free photoelectrochemical immunosensor and aptasensor: Application to the determination of thrombin and anti-cholera toxin antibody., Yao, Wenjuan, Le Goff Alan, Spinelli Nicolas, Holzinger Michael, Diao Guo-Wang, Shan Dan, Defrancq Eric, and Cosnier Serge , Biosens. Bioelectron., Volume 42, p.556–562, (2013)

Efficient Surface Patterning of Oligonucleotides Inside a Glass Capillary through Oxime Bond Formation., Dendane, Nabil, Hoang Antoine, Guillard Ludovic, Defrancq Eric, Vinet Francoise, and Dumy Pascal , Bioconjug. Chem., Volume 18, Number 3, p.671–676, (2007)

Efficient Inhibition of Telomerase by Nickel-Salophen Complexes., Lecarme, Laureline, Prado Enora, De Rache Aurore, Nicolau-Travers Marie-Laure, Gellon Gisèle, Dejeu Jérôme, Lavergne Thomas, Jamet Hélène, Gomez Dennis, Mergny Jean-Louis, et al. , ChemMedChem, Volume 11, Number 11, p.1133–1136, (2016)

Efficient conjugation of oligonucleotides through aromatic oxime formation., Murat, Pierre, Spinelli Nicolas, Dumy Pascal, and Defrancq Eric , Bioorg. Med. Chem. Lett., Volume 19, Number 23, p.6534–6537, (2009)

Efficient Buchwald-Hartwig-Migita Cross-Coupling for DNA Thio-glycoconjugation., Probst, Nicolas, Lartia Remy, Thery Oceane, Alami Mouad, Defrancq Eric, and Messaoudi Samir. , Chem. - A Eur. J., Volume 24, Number 8, p.1795–1800, (2018)

Direct Detection of Low-Molecular-Weight Compounds in 2D and 3D Aptasensors by Biolayer Interferometry, Vignon, Anthony, Flaget Arthur, Michelas Maxime, Djeghdir Mehdi, Defrancq Eric, Guerente Liliane, Spinelli Nicolas, Van der Heyden Angeline, and Dejeu Jérôme , ACS Sensors, 08/2020, Volume 5, Issue 8, p.2326 – 2330, (2020)

Design and synthesis of novel hybrid metal complex-DNA conjugates: Key building blocks for multimetallic linear DNA nanoarrays., Ghosh, Sumana, Pignot-Paintrand Isabelle, Dumy Pascal, and Defrancq Eric , Org. Biomol. Chem., Volume 7, Number 13, p.2729–2737, (2009)

Controlled Density Patterning of Tolylterpyridine-Tagged Oligonucleotides., Tuccitto, Nunzio, Giamblanco Nicoletta, Ghosh Sumana, Spampinato Valentina, Labbe Pierre, Dumy Pascal, Quici Silvio, Marletta Giovanni, Defrancq Eric, and Licciardello Antonino. , Langmuir, Volume 27, Number 14, p.8595–8599, (2011)

Construction of anti-parallel G-quadruplexes through sequential templated click., Bonnet, Romaric, Lavergne Thomas, Gennaro Béatrice, Spinelli Nicolas, and Defrancq Eric , Chem. Commun. (Cambridge, United Kingdom), Volume 51, Number 23, p.4850–4853, (2015)

Constrained G4 structures unveil topology specificity of known and new G4 binding proteins, Pipier, A, Devaux A, Lavergne T, Adrait A, Couté Y, Britton S, Calsou P, Riou J-F, Defrancq Eric, and Gomez D , Scientific Reports, 06/2021, Volume 11, p.13469, (2021)

Conformational transition in SPR experiments: impact of spacer length, immobilization mode and aptamer density on signal sign and amplitude, Pons, Marina, Perenon Marine, Bonnet Hugues, Gillon Emilie, Vallée Celio, Coche-Guérente Liliane, Defrancq Eric, Spinelli Nicolas, Van der Heyden Angeline, and Dejeu Jérôme , Analyst, 08/2022, Volume 147, p.4197-4205, (2022)

Cobalt(III)porphyrin to target G-quadruplex DNA., Sabater, Laurent, Fang Pei-Ju, Chang Chi-Fon, De Rache Aurore, Prado Enora, Dejeu Jérôme, Garofalo Antonio, Lin Jung-Hsin, Mergny Jean-Louis, Defrancq Eric, et al. , Dalt. Trans., Volume 44, Number 8, p.3701–3707, (2015)

Closer to nature: an ATP-driven bioinspired catalytic oxidation process., Stefan, Loic, Duret Damien, Spinelli Nicolas, Defrancq Eric, and Monchaud David. , Chem. Commun. (Cambridge, United Kingdom), Volume 49, Number 15, p.1500–1502, (2013)

Click-click chemistry on a peptidic scaffold for easy access to tetrameric DNA structures., Bonnet, Romaric, Murat Pierre, Spinelli Nicolas, and Defrancq Eric , Chem. Commun. (Cambridge, United Kingdom), Volume 48, Number 48, p.5992–5994, (2012)

Characterization of a modified gold platform for the development of a label-free anti-thrombin aptasensor., Jalit, Yamile, Gutierrez Fabiana A., Dubacheva Galina V., Goyer Cedric, Guerente Liliane, Defrancq Eric, Labbe Pierre, Rivas Gustavo A., and Rodriguez Marcela C. , Biosens. Bioelectron., Volume 41, p.424–429, (2013)

Binding of metalloporphyrins to G-quadruplex DNA: The role of the central metal., Dejeu, Jérôme, Lavergne Thomas, Nora Jeremie Della, Defrancq Eric, and Pratviel Genevieve. , Inorganica Chim. Acta, Volume 452, p.98–103, (2016)

Assessment of the Full Compatibility of Copper(I)-Catalyzed Alkyne-Azide Cycloaddition and Oxime Click Reactions for bis-Labelling of Oligonucleotides., Estalayo-Adrian, Sandra, Lartia Remy, Meyer Albert, Vasseur Jean-Jacques, Morvan Francois, and Defrancq Eric , ChemistryOpen, Volume 4, Number 2, p.169–173, (2015)

Assessment of presumed small-molecule ligands of telomeric i-DNA by BioLayer Interferometry (BLI), Bonnet, Hugues, Morel Maeva, Devaux Alexandre, Boissieras Joseph, Granzhan Anton, Elias Benjamin, Lavergne Thomas, Dejeu Jérôme, and Defrancq Eric , Chem. Commun., 04/2022, Volume 58, p.5116-5119, (2022)

Aldehydic Oligonucleotide: A Key Intermediate for the Preparation of Oligonucleotide Conjugates Through Oxime Bond Formation., Spinelli, Nicolas, Singh Y, Defrancq Eric, and Dumy Pascal , Nucleosides. Nucleotides Nucleic Acids, Volume 26, Number 8-9, p.883–887, (2007)

Access to a stabilized i-motif DNA structure through four successive ligation reactions on a cyclopeptide scaffold, Devaux, Alexandre, Bonnat Laureen, Lavergne Thomas, and Defrancq Eric , Org. Biomol. Chem., 07/2020, Volume 18, p.6394-6406, (2020)