Département de chimie moléculaire

The nickel(II) complex of guanidinium phenyl porphyrin, a specific G-quadruplex ligand, targets telomeres and leads to POT1 mislocalization in culture cells., Sabater, Laurent, Nicolau-Travers Marie-Laure, De Rache Aurore, Prado Enora, Dejeu Jérôme, Bombarde Oriane, Lacroix Joris, Calsou Patrick, Defrancq Eric, Mergny Jean-Louis, et al. , JBIC, J. Biol. Inorg. Chem., Volume 20, Number 4, p.729–738, (2015)

Parameters influencing the photo-induced electron transfer from tryptophan-containing peptides to a RuII complex: a systematic study., Garnir, Kevin, Estalayo-Adrian Sandra, Lartia Remy, De Winter Julien, Defrancq Eric, Surin Mathieu, Lemaur Vincent, Gerbaux Pascal, and Moucheron Cecile. , Faraday Discuss., Volume 185, p.267–284, (2015)

Sensor Based on Aptamer Folding to Detect Low-Molecular Weight Analytes., Osypova, Alina, Thakar Dhruv, Dejeu Jérôme, Bonnet Hugues, Van der Heyden Angeline, Dubacheva Galina V., Richter Ralf P., Defrancq Eric, Spinelli Nicolas, Guerente Liliane, et al. , Anal. Chem. (Washington, DC, United States), Volume 87, Number 15, p.7566–7574, (2015)

Binding of metalloporphyrins to G-quadruplex DNA: The role of the central metal., Dejeu, Jérôme, Lavergne Thomas, Nora Jeremie Della, Defrancq Eric, and Pratviel Genevieve. , Inorganica Chim. Acta, Volume 452, p.98–103, (2016)

Efficient Inhibition of Telomerase by Nickel-Salophen Complexes., Lecarme, Laureline, Prado Enora, De Rache Aurore, Nicolau-Travers Marie-Laure, Gellon Gisèle, Dejeu Jérôme, Lavergne Thomas, Jamet Hélène, Gomez Dennis, Mergny Jean-Louis, et al. , ChemMedChem, Volume 11, Number 11, p.1133–1136, (2016)

Highly DNA-Photoreactive Ruthenium 1,4,5,8-Tetraazaphenanthrene Complex Conjugated to the TAT Peptide: Efficient Vectorization inside HeLa Cells without Phototoxicity - The Importance of Cellular Distribution., Marcelis, Lionel, Kajouj Sofia, Ghesquiere Jonathan, Fettweis Gregory, Coupienne Isabelle, Lartia Remy, Surin Mathieu, Defrancq Eric, Piette Jacques, Moucheron Cecile, et al. , Eur. J. Inorg. Chem., Volume 2016, Number 18, p.2902–2911, (2016)

Highly Sensitive Bisphenol-A Electrochemical Aptasensor Based on Poly(Pyrrole-Nitrilotriacetic Acid)-Aptamer Film., Kazane, Imen, Gorgy Karine, Gondran Chantal, Spinelli Nicolas, Zazoua Ali, Defrancq Eric, and Cosnier Serge , Anal. Chem. (Washington, DC, United States), Volume 88, Number 14, p.7268–7273, (2016)

A label-free photoelectrochemical cocaine aptasensor based on an electropolymerized ruthenium-intercalator complex., Haddache, Fatima, Le Goff Alan, Spinelli Nicolas, Gairola Priyanka, Gorgy Karine, Gondran Chantal, Defrancq Eric, and Cosnier Serge , Electrochim. Acta, Volume 219, p.82–87, (2016)

Prefolded Synthetic G-Quartets Display Enhanced Bioinspired Properties., Flack, Theodore, Constantin Thibaut, Penasse Sylvain, Dejeu Jérôme, Gennaro Béatrice, Jourdan Muriel, Laguerre Aurelien, Pirrotta Marc, Monchaud David, Spinelli Nicolas, et al. , Chem. - A Eur. J., Volume 22, Number 5, p.1760–1767, (2016)

Templated Formation of Discrete RNA and DNA:RNA Hybrid G-Quadruplexes and Their Interactions with Targeting Ligands., Bonnat, Laureen, Dejeu Jérôme, Bonnet Hugues, Gennaro Béatrice, Jarjayes Olivier, Thomas Fabrice, Lavergne Thomas, and Defrancq Eric , Chem. - A Eur. J., Volume 22, Number 9, p.3139–3147, (2016)

New Ruthenium-Based Probes for Selective G-Quadruplex Targeting., Piraux, Guillaume, Bar Laure, Abraham Michael, Lavergne Thomas, Jamet Hélène, Dejeu Jérôme, Marcelis Lionel, Defrancq Eric, and Elias Benjamin. , Chem. - A Eur. J., Volume 23, Number 49, p.11872–11880, (2017)

An oxime-based glycocluster microarray., Hoang, Antoine, Laigre Eugenie, Goyard David, Defrancq Eric, Vinet Francoise, Dumy Pascal, and Renaudet Olivier , Org. Biomol. Chem., Volume 15, Number 24, p.5135–5139, (2017)

Palladium-Mediated Labeling of Nucleic Acids., Defrancq, Eric, and Messaoudi Samir. , ChemBioChem, Volume 18, Number 5, p.426–431, (2017)

The pKa value of the proximal water molecule trans to a high-valent MnV=O porphyrin: towards the control of reactivity by pH., Saint-Germes, Laurie, Bar Laure, Dejeu Jérôme, Spinelli Nicolas, Defrancq Eric, and Pratviel Genevieve. , Dalt. Trans., Volume 46, Number 36, p.12088–12094, (2017)

Template-mediated stabilization of a DNA G-quadruplex formed in the HIV-1 promoter and comparative binding studies., Bonnat, Laureen, Bar Laure, Gennaro Béatrice, Bonnet Hugues, Jarjayes Olivier, Thomas Fabrice, Dejeu Jérôme, Defrancq Eric, and Lavergne Thomas , Chem. - A Eur. J., Volume 23, Number 23, p.5602–5613, (2017)

Efficient Buchwald-Hartwig-Migita Cross-Coupling for DNA Thio-glycoconjugation., Probst, Nicolas, Lartia Remy, Thery Oceane, Alami Mouad, Defrancq Eric, and Messaoudi Samir. , Chem. - A Eur. J., Volume 24, Number 8, p.1795–1800, (2018)

Impact of Conformational Transitions on SPR Signals-Theoretical Treatment and Application in Small Analytes/Aptamer Recognition., Dejeu, Jérôme, Bonnet Hugues, Spinelli Nicolas, Defrancq Eric, Guerente Liliane, Van der Heyden Angeline, and Labbe Pierre. , J. Phys. Chem. C, Volume 122, Number 37, p.21521–21530, (2018)

Influence of the SPR Experimental Conditions on the G-Quadruplex DNA Recognition by Porphyrin Derivatives., Prado, E, Bonnat L, Bonnet Hugues, Lavergne Thomas, Van der Heyden Angeline, Pratviel G, Dejeu Jérôme, and Defrancq Eric , Langmuir, Volume 34, Number 43, p.13057–13064, (2018)

Synthesis and photophysical studies of a multivalent photoreactive RuII-calix[4]arene complex bearing RGD-containing cyclopentapeptides., Kajouj, Sofia, Marcelis Lionel, Mattiuzzi Alice, Grassin Adrien, Dufour Damien, Van Antwerpen Pierre, Boturyn Didier, Defrancq Eric, Surin Mathieu, De Winter Julien, et al. , Beilstein J. Org. Chem., Volume 14, p.1758–1768, (2018)

Towards the Development of Photo-Reactive Ruthenium(II) Complexes Targeting Telomeric G-Quadruplex DNA., Weynand, Justin, Diman Aurelie, Abraham Michael, Marcelis Lionel, Jamet Hélène, Decottignies Anabelle, Dejeu Jérôme, Defrancq Eric, and Elias Benjamin. , Chem. - A Eur. J., Volume 24, Number 72, p.19216–19227, (2018)

Influence of Aptamer Surface Coverage on Small Target Recognition: A SPR and QCM-D Comparative Study, MacDonald, Hannah, Bonnet Hugues, Van der Heyden Angeline, Defrancq Eric, Spinelli Nicolas, Guerente Liliane, and Dejeu Jérôme , J. Phys. Chem. C, Volume 123, p.13561–13568, (2019)

Photodetection of DNA mismatches by dissymmetric Ru(ii) acridine based complexes, Gillard, Martin, Laramee-Milette Baptiste, Deraedt Quentin, Hanan Garry S., Loiseau Frédérique, Dejeu Jérôme, Defrancq Eric, Elias Benjamin., and Marcelis Lionel , Inorg. Chem. Front., p.2260-2270, (2019)

Scaffold stabilization of a G-triplex and study of its interactions with G-quadruplex targeting ligands., Bonnat, Laureen, Dautriche Maelle, Saidi Taous, Revol-Cavalier Johana, Dejeu Jérôme, Defrancq Eric, and Lavergne Thomas , Org. Biomol. Chem., Volume 17, p.8726–8736, (2019)

Scaffold stabilization of a G-triplex and study of its interactions with G-quadruplex targeting ligands, Bonnat, Laureen, Dautriche Maelle, Saidi Taous, Revol-Cavalier Johana, Dejeu Jérôme, Defrancq Eric, and Lavergne Thomas , Org. Biomol. Chem., Volume 17, p.8726-8736, (2019)

Targeting G-Rich DNA Structures with Photoreactive Bis-Cyclometallated Iridium(III) Complexes, Weynand, Justin, Bonnet Hugues, Loiseau Frédérique, Ravanat Jean-Luc, Dejeu Jérôme, Defrancq Eric, and Elias Benjamin. , Chemistry – A European Journal, Volume 25, p.12730-12739, (2019)

Access to a stabilized i-motif DNA structure through four successive ligation reactions on a cyclopeptide scaffold, Devaux, Alexandre, Bonnat Laureen, Lavergne Thomas, and Defrancq Eric , Org. Biomol. Chem., 07/2020, Volume 18, p.6394-6406, (2020)

Direct Detection of Low-Molecular-Weight Compounds in 2D and 3D Aptasensors by Biolayer Interferometry, Vignon, Anthony, Flaget Arthur, Michelas Maxime, Djeghdir Mehdi, Defrancq Eric, Guerente Liliane, Spinelli Nicolas, Van der Heyden Angeline, and Dejeu Jérôme , ACS Sensors, 08/2020, Volume 5, Issue 8, p.2326 – 2330, (2020)

Flexible RuII Schiff Base Complexes: G-Quadruplex DNA Binding and Photo-Induced Cancer Cell Death, Gillard, Martin, Weynand Justin, Bonnet Hugues, Loiseau Frédérique, Decottignies Anabelle, Dejeu Jérôme, Defrancq Eric, and Elias Benjamin , Chemistry – A European Journal, Volume 26, p.13849-13860, (2020)

Post-synthetic transamination at position N4 of cytosine in oligonucleotides assembled with routinely used phosphoramidites, Lartia, Remy, Vallée Coelio, and Defrancq Eric , Org. Biomol. Chem., Volume 18, p.9632-9638, (2020)

Post-synthetic transamination at position N4 of cytosine in oligonucleotides assembled with routinely used phosphoramidites, Lartia, Remy, Vallée Coelio, and Defrancq Eric , Org. Biomol. Chem., 11/2020, p.-, (2020)

Redox-Active Bis-Cyclometalated Iridium(III) Complex as a DNA Photo-Cleaving Agent, Weynand, Justin, Moreno-Betancourt Angélica, Loiseau Frédérique, Berthet Nathalie, Defrancq Eric, and Elias Benjamin , Inorganic Chemistry, 01/2020, Volume 59, p.2426-2433, (2020)

Surface plasmon resonance study of the interaction of N-methyl mesoporphyrin IX with G-quadruplex DNA, Perenon, M, Bonnet Hugues, Lavergne Thomas, Dejeu Jérôme, and Defrancq Eric , Phys. Chem. Chem. Phys., 02/2020, Volume 22, p.4158-4164, (2020)

Constrained G4 structures unveil topology specificity of known and new G4 binding proteins, Pipier, A, Devaux A, Lavergne T, Adrait A, Couté Y, Britton S, Calsou P, Riou J-F, Defrancq Eric, and Gomez D , Scientific Reports, 06/2021, Volume 11, p.13469, (2021)

Negative SPR Signals during Low Molecular Weight Analyte Recognition, Bonnet, Hugues, Coche-Guérente L., Defrancq Eric, Spinelli N., Van der Heyden Angeline, and Dejeu Jérôme , Analytical Chemistry, 02/2021, Volume 93, Issue 8, p.4134–4140, (2021)

Recent progress in the design of G-quadruplex based electrochemical aptasensors, Dejeu, Jérôme, Van der Heyden A., Spinelli N., Defrancq Eric, and Coche-Guérente L. , Current Opinion in Electrochemistry, 07/2021, p.100812, (2021)

Transcription-associated topoisomerase 2α activity is a major effector of cytotoxicity induced by G-quadruplex ligands, Bossaert, Madeleine, Pipier Angélique, Riou Jean-Francois, Noirot Céline, Nguyễn Linh-Trang, Serre Remy-Felix, Bouchez Olivier, Defrancq Eric, Calsou Patrick, Britton Sébastien, et al. , eLife, 06/2021, Volume 10, p.e65184, (2021)

Assessment of presumed small-molecule ligands of telomeric i-DNA by BioLayer Interferometry (BLI), Bonnet, Hugues, Morel Maeva, Devaux Alexandre, Boissieras Joseph, Granzhan Anton, Elias Benjamin, Lavergne Thomas, Dejeu Jérôme, and Defrancq Eric , Chem. Commun., 04/2022, Volume 58, p.5116-5119, (2022)

Conformational transition in SPR experiments: impact of spacer length, immobilization mode and aptamer density on signal sign and amplitude, Pons, Marina, Perenon Marine, Bonnet Hugues, Gillon Emilie, Vallée Celio, Coche-Guérente Liliane, Defrancq Eric, Spinelli Nicolas, Van der Heyden Angeline, and Dejeu Jérôme , Analyst, 08/2022, Volume 147, p.4197-4205, (2022)

Photo-induced telomeric DNA damage in human cancer cells, Weynand, Justin, Episkopou Harikleia, Le Berre Gabriel, Gillard Martin, Dejeu Jérôme, Decottignies Anabelle, Defrancq Eric, and Elias Benjamin , RSC Chem. Biol., 10/2022, Volume 3, p.1375, (2022)

Photo-oxidizing Ruthenium(II) Complexes with Enhanced Visible Light Absorption and G-quadruplex DNA Binding Abilities, Gillard, Martin, Piraux Guillaume, Daenen Martin, Abraham Michael, Troian-Gautier Ludovic, Bar Laure, Bonnet Hugues, Loiseau Frédérique, Jamet Hélène, Dejeu Jérôme, et al. , Chemistry – A European Journal, 08/2022, Volume 28, (2022)

Novel Synthesis of IMC-48 and Affinity Evaluation with Different i-Motif DNA Sequences, Berthiol, Florian, Boissieras Joseph, Bonnet Hugues, Pierrot Marie, Philouze Christian, Poisson Jean-François, Granzhan Anton, Dejeu Jérôme, and Defrancq Eric , Molecules, 01/2023, Volume 28, (2023)