Département de chimie moléculaire

Aldehydic Oligonucleotide: A Key Intermediate for the Preparation of Oligonucleotide Conjugates Through Oxime Bond Formation., Spinelli, Nicolas, Singh Y, Defrancq Eric, and Dumy Pascal , Nucleosides. Nucleotides Nucleic Acids, Volume 26, Number 8-9, p.883–887, (2007)

Click-click chemistry on a peptidic scaffold for easy access to tetrameric DNA structures., Bonnet, Romaric, Murat Pierre, Spinelli Nicolas, and Defrancq Eric , Chem. Commun. (Cambridge, United Kingdom), Volume 48, Number 48, p.5992–5994, (2012)

Closer to nature: an ATP-driven bioinspired catalytic oxidation process., Stefan, Loic, Duret Damien, Spinelli Nicolas, Defrancq Eric, and Monchaud David. , Chem. Commun. (Cambridge, United Kingdom), Volume 49, Number 15, p.1500–1502, (2013)

Construction of anti-parallel G-quadruplexes through sequential templated click., Bonnet, Romaric, Lavergne Thomas, Gennaro Béatrice, Spinelli Nicolas, and Defrancq Eric , Chem. Commun. (Cambridge, United Kingdom), Volume 51, Number 23, p.4850–4853, (2015)

Direct Detection of Low-Molecular-Weight Compounds in 2D and 3D Aptasensors by Biolayer Interferometry, Vignon, Anthony, Flaget Arthur, Michelas Maxime, Djeghdir Mehdi, Defrancq Eric, Guerente Liliane, Spinelli Nicolas, Van der Heyden Angeline, and Dejeu Jérôme , ACS Sensors, 08/2020, Volume 5, Issue 8, p.2326 – 2330, (2020)

Efficient conjugation of oligonucleotides through aromatic oxime formation., Murat, Pierre, Spinelli Nicolas, Dumy Pascal, and Defrancq Eric , Bioorg. Med. Chem. Lett., Volume 19, Number 23, p.6534–6537, (2009)

Electrogenerated trisbipyridyl Ru(II)-/nitrilotriacetic-polypyrene copolymer for the easy fabrication of label-free photoelectrochemical immunosensor and aptasensor: Application to the determination of thrombin and anti-cholera toxin antibody., Yao, Wenjuan, Le Goff Alan, Spinelli Nicolas, Holzinger Michael, Diao Guo-Wang, Shan Dan, Defrancq Eric, and Cosnier Serge , Biosens. Bioelectron., Volume 42, p.556–562, (2013)

Glycoclusters on oligonucleotide and PNA scaffolds: synthesis and applications., Spinelli, Nicolas, Defrancq Eric, and Morvan Francois. , Chem. Soc. Rev., Volume 42, Number 11, p.4557–4573, (2013)

High Affinity Glycodendrimers for the Lectin LecB from Pseudomonas aeruginosa., Berthet, Nathalie, Thomas Baptiste, Bossu Isabelle, Dufour Emilie, Gillon Emilie, Garcia Julian, Spinelli Nicolas, Imberty Anne, Dumy Pascal, and Renaudet Olivier , Bioconjug. Chem., Volume 24, Number 9, p.1598–1611, (2013)

Highly Sensitive Bisphenol-A Electrochemical Aptasensor Based on Poly(Pyrrole-Nitrilotriacetic Acid)-Aptamer Film., Kazane, Imen, Gorgy Karine, Gondran Chantal, Spinelli Nicolas, Zazoua Ali, Defrancq Eric, and Cosnier Serge , Anal. Chem. (Washington, DC, United States), Volume 88, Number 14, p.7268–7273, (2016)

Impact of Conformational Transitions on SPR Signals-Theoretical Treatment and Application in Small Analytes/Aptamer Recognition., Dejeu, Jérôme, Bonnet Hugues, Spinelli Nicolas, Defrancq Eric, Guerente Liliane, Van der Heyden Angeline, and Labbe Pierre. , J. Phys. Chem. C, Volume 122, Number 37, p.21521–21530, (2018)

Influence of Aptamer Surface Coverage on Small Target Recognition: A SPR and QCM-D Comparative Study, MacDonald, Hannah, Bonnet Hugues, Van der Heyden Angeline, Defrancq Eric, Spinelli Nicolas, Guerente Liliane, and Dejeu Jérôme , J. Phys. Chem. C, Volume 123, p.13561–13568, (2019)

Label-free impedimetric thrombin sensor based on poly(pyrrole-nitrilotriacetic acid)-aptamer film, Xu, Hui, Gorgy Karine, Gondran Chantal, Le Goff Alan, Spinelli Nicolas, Lopez Christian, Defrancq Eric, and Cosnier Serge , Biosensors and Bioelectronics, Volume 41, p.90 - 95, (2013)

A label-free photoelectrochemical cocaine aptasensor based on an electropolymerized ruthenium-intercalator complex., Haddache, Fatima, Le Goff Alan, Spinelli Nicolas, Gairola Priyanka, Gorgy Karine, Gondran Chantal, Defrancq Eric, and Cosnier Serge , Electrochim. Acta, Volume 219, p.82–87, (2016)

Label-free photoelectrochemical detection of double-stranded HIV DNA by means of a metallointercalator-functionalized electrogenerated polymer., Haddache, Fatima, Le Goff Alan, Reuillard Bertrand, Gorgy Karine, Gondran Chantal, Spinelli Nicolas, Defrancq Eric, and Cosnier Serge , Chem. - A Eur. J., Volume 20, Number 47, p.15555–15560, (2014)

Macrocyclic Host-Dye Reporter for Sensitive Sandwich-Type Fluorescent Aptamer Sensor., Yang, Cheng, Spinelli Nicolas, Perrier Sandrine, Defrancq Eric, and Peyrin Eric. , Anal. Chem. (Washington, DC, United States), Volume 87, Number 6, p.3139–3143, (2015)

Molecular engineering of biomolecules for nanobio-sciences., Renaudet, Olivier, Garcia Julian, Boturyn Didier, Spinelli Nicolas, Defrancq Eric, Labbe Pierre, and Dumy Pascal , Int. J. Nanotechnol., Volume 7, Number 4/5/6/7/8, p.738–752, (2010)

A multi-ligation strategy for the synthesis of heterofunctionalized glycosylated scaffolds., Thomas, Baptiste, Fiore Michele, Daskhan Gour Chand, Spinelli Nicolas, and Renaudet Olivier , Chem. Commun. (Cambridge, United Kingdom), Volume 51, Number 25, p.5436–5439, (2015)

New Solid Support for the Synthesis of 3'-Oligonucleotide Conjugates through Glyoxylic Oxime Bond Formation., Spinelli, Nicolas, Edupuganti Om Prakash, Defrancq Eric, and Dumy Pascal , Org. Lett., Volume 9, Number 2, p.219–222, (2007)

A novel conformationally constrained parallel G quadruplex., Murat, Pierre, Cressend Delphine, Spinelli Nicolas, Van der Heyden Angeline, Labbe Pierre, Dumy Pascal, and Defrancq Eric , ChemBioChem, Volume 9, Number 16, p.2588–2591, (2008)

Oligonucleotide Sequential Bis-Conjugation via Click-Oxime and Click-Huisgen Procedures., Meyer, Albert, Spinelli Nicolas, Dumy Pascal, Vasseur Jean-Jacques, Morvan Francois, and Defrancq Eric , J. Org. Chem., Volume 75, Number 11, p.3927–3930, (2010)

Optimization of GOPS-Based Functionalization Process and Impact of Aptamer Grafting on the Si Nanonet FET Electrical Properties as First Steps towards Thrombin Electrical Detection, Vallejo-Perez, Monica, Ternon Céline, Spinelli Nicolas, Morisot Fanny, Theodorou Christoforos, Jayakumar Ganesh, Hellström Per-Erik, Mouis Mireille, Rapenne Laetitia, Mescot Xavier, et al. , Nanomaterials, 09/2020, Volume 10, (2020)

The pKa value of the proximal water molecule trans to a high-valent MnV=O porphyrin: towards the control of reactivity by pH., Saint-Germes, Laurie, Bar Laure, Dejeu Jérôme, Spinelli Nicolas, Defrancq Eric, and Pratviel Genevieve. , Dalt. Trans., Volume 46, Number 36, p.12088–12094, (2017)

Prefolded Synthetic G-Quartets Display Enhanced Bioinspired Properties., Flack, Theodore, Constantin Thibaut, Penasse Sylvain, Dejeu Jérôme, Gennaro Béatrice, Jourdan Muriel, Laguerre Aurelien, Pirrotta Marc, Monchaud David, Spinelli Nicolas, et al. , Chem. - A Eur. J., Volume 22, Number 5, p.1760–1767, (2016)

Sensor Based on Aptamer Folding to Detect Low-Molecular Weight Analytes., Osypova, Alina, Thakar Dhruv, Dejeu Jérôme, Bonnet Hugues, Van der Heyden Angeline, Dubacheva Galina V., Richter Ralf P., Defrancq Eric, Spinelli Nicolas, Guerente Liliane, et al. , Anal. Chem. (Washington, DC, United States), Volume 87, Number 15, p.7566–7574, (2015)

Surface-immobilized DNAzyme-type biocatalysis., Stefan, Loic, Lavergne Thomas, Spinelli Nicolas, Defrancq Eric, and Monchaud David. , Nanoscale, Volume 6, Number 5, p.2693–2701, (2014)

Synthesis and characterization of oligonucleotide conjugates bearing electroactive labels., Moreau, Julie, Dendane Nabil, Schollhorn Bernd, Spinelli Nicolas, Fave Claire, and Defrancq Eric , Bioorg. Med. Chem. Lett., Volume 23, Number 4, p.955–958, (2013)

Template-Assembled Synthetic G-Quadruplex (TASQ): A Useful System for Investigating the Interactions of Ligands with Constrained Quadruplex Topologies., Murat, Pierre, Bonnet Romaric, Van der Heyden Angeline, Spinelli Nicolas, Labbe Pierre, Monchaud David, Teulade-Fichou Marie-Paule, Dumy Pascal, and Defrancq Eric , Chem. - A Eur. J., Volume 16, Number 20, p.6106–6114, S6106/1–S6106/16, (2010)

The Use of a Peptidic Scaffold for the Formation of Stable Guanine Tetrads: Control of a H-bonded Pattern in Water., Murat, Pierre, Gennaro Béatrice, Garcia Julian, Spinelli Nicolas, Dumy Pascal, and Defrancq Eric , Chem. - A Eur. J., Volume 17, Number 21, p.5791–5795, S5791/1–S5791/21, (2011)